Ser-2030, but not Ser-2808, is the major phosphorylation site in cardiac ryanodine receptors responding to protein kinase A activation upon β-adrenergic stimulation in normal and failing hearts

We have recently shown that RyR2 (cardiac ryanodine receptor) is phosphorylated by PKA (protein kinase A/cAMP-dependent protein kinase) at two major sites, Ser-2030 and Ser-2808. In the present study, we examined the properties and physiological relevance of phosphorylation of these two sites. Using...

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Bibliografiske detaljer
Main Authors: Xiao, Bailong, Zhong, Guofeng, Obayashi, Masakazu, Yang, Dongmei, Chen, Keyun, Walsh, Michael P., Shimoni, Yakhin, Cheng, Heping, ter Keurs, Henk, Chen, S. R. Wayne
Format: Artigo
Sprog:Inglês
Udgivet: Portland Press Ltd. 2006
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1449991/
https://ncbi.nlm.nih.gov/pubmed/16483256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20060116
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