Hyperphosphorylation of the Cardiac Ryanodine Receptor at Serine 2808 Is Not Involved in Cardiac Dysfunction after Myocardial Infarction

RATIONALE: Abnormal behavior of the cardiac ryanodine receptor (RyR2) has been linked to cardiac arrhythmias and heart failure (HF) after Myocardial infarction (MI). It has been proposed that protein kinase A (PKA) hyperphosphorylation of the RyR2 at a single residue, Ser-2808 is a critical mediator...

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Hauptverfasser: Zhang, Hongyu, Makarewich, Catherine, Kubo, Hajime, Wang, Wei, Duran, Jason, Li, Ying, Berretta, Remus, Koch, Walter J., Chen, Xiongwen, Gao, Erhe, Valdivia, Hector, Houser, Steven R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3322671/
https://ncbi.nlm.nih.gov/pubmed/22302785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.111.255158
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