Transient overexpression of mitochondrial transcription factor A (TFAM) is sufficient to stimulate mitochondrial DNA transcription, but not sufficient to increase mtDNA copy number in cultured cells

Mitochondrial transcription factor A (TFAM) stimulates transcription from mitochondrial DNA (mtDNA) promoters in vitro and in organello. To investigate whether changes of TFAM levels also modulate transcription and replication in situ, the protein was transiently overexpressed in cultured cells. Mit...

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Detalles Bibliográficos

Publicado en:	Nucleic Acids Res
Principais autores:	Maniura-Weber, Katharina, Goffart, Steffi, Garstka, Heike L., Montoya, Julio, Wiesner, Rudolf J.
Formato:	Artigo
Idioma:	Inglês
Publicado:	Oxford University Press 2004
Assuntos:	Articles
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC534614/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15547250/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkh921
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