From cells, to mice, to target: Characterization of NEU-1053 (SB-443342) and its analogs for treatment of human African trypanosomiasis

Human African Trypanosomiasis is a neglected tropical disease that is lethal if left untreated. Existing therapeutics have limited efficacy and severe associated toxicities. 2-(2-(((3-((1H–Benzo[d]imidazol-2-yl)amino)propyl)amino)methyl)-4,6-dichloro-1H–indol-1-yl)ethan-1-ol (NEU-1053) has recently...

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Vydáno v:ACS Infect Dis
Hlavní autoři: Devine, William G., Diaz-Gonzalez, Rosario, Ceballos-Perez, Gloria, Rojas, Domingo, Satoh, Takashi, Tear, Westley, Ranade, Ranae M., Barros-Álvarez, Ximena, Hol, Wim G. J., Buckner, Frederick S., Navarro, Miguel, Pollastri, Michael P.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5346068/
https://ncbi.nlm.nih.gov/pubmed/28110521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.6b00202
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