Genome-Wide Analysis of Clopidogrel Active Metabolite Levels Identifies Novel Variants that Influence Antiplatelet Response

Clopidogrel is one of the most commonly used therapeutics for secondary prevention of cardiovascular events in patients with acute coronary syndromes. However, substantial inter-individual variation in clopidogrel response has been documented, resulting in suboptimal therapy and an increased risk of...

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Veröffentlicht in:Pharmacogenet Genomics
Hauptverfasser: Backman, Joshua D., O’Connell, Jeffrey R., Tanner, Keith, Peer, Cody J., Figg, William D., Spencer, Shawn D., Mitchell, Braxton D., Shuldiner., Alan R., Yerges-Armstrong, Laura M., Horenstein, Richard B., Lewis, Joshua P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5346037/
https://ncbi.nlm.nih.gov/pubmed/28207573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0000000000000272
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