Integrated Regulation of Hepatic Lipid and Glucose Metabolism by ATGL and FoxO Proteins

FoxO proteins are major targets of insulin action. Adipose triacylglycerol (TAG) lipase mediates the first step in TAG hydrolysis and FoxO1 stimulates ATGL expression in adipose tissue. Here, we report that FoxO1 also stimulates ATGL and suppresses expression of its inhibitor, the G0/G1 switch gene...

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Pubblicato in:Cell Rep
Autori principali: Zhang, Wenwei, Bu, So Young, Mashek, Mara T., O-Sullivan, InSug, Sibai, Zakaria, Khan, Salmaan A., Ikayeva, Olga, Newgard, Christopher B., Mashek, Douglas G., Unterman, Terry G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5346032/
https://ncbi.nlm.nih.gov/pubmed/27050511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.03.021
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