FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization

FoxO proteins are major targets of insulin action. To better define the role of FoxO1 in mediating insulin effects in the liver, we generated liver-specific insulin receptor knockout (LIRKO) and IR/FoxO1 double knockout (LIRFKO) mice. Here we show that LIRKO mice are severely insulin resistant based...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: O-Sullivan, InSug, Zhang, Wenwei, Wasserman, David H., Liew, Chong Wee, Liu, Jonathan, Paik, Jihye, DePinho, Ronald A., Stolz, Donna Beer, Kahn, C. Ronald, Schwartz, Michael W., Unterman, Terry G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4755301/
https://ncbi.nlm.nih.gov/pubmed/25963540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8079
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