FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization

FoxO proteins are major targets of insulin action. To better define the role of FoxO1 in mediating insulin effects in the liver, we generated liver-specific insulin receptor knockout (LIRKO) and IR/FoxO1 double knockout (LIRFKO) mice. Here we show that LIRKO mice are severely insulin resistant based...

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Bibliografiset tiedot
Julkaisussa:Nat Commun
Päätekijät: O-Sullivan, InSug, Zhang, Wenwei, Wasserman, David H., Liew, Chong Wee, Liu, Jonathan, Paik, Jihye, DePinho, Ronald A., Stolz, Donna Beer, Kahn, C. Ronald, Schwartz, Michael W., Unterman, Terry G.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2015
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4755301/
https://ncbi.nlm.nih.gov/pubmed/25963540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8079
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