p53-related protein kinase confers poor prognosis and represents a novel therapeutic target in multiple myeloma

p53-related protein kinase (TP53RK, also known as PRPK) is an upstream kinase that phosphorylates (serine residue Ser15) and mediates p53 activity. Here we show that TP53RK confers poor prognosis in multiple myeloma (MM) patients, and, conversely, that TP53RK knockdown inhibits p53 phosphorylation a...

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Pubblicato in:Blood
Autori principali: Hideshima, Teru, Cottini, Francesca, Nozawa, Yoshihisa, Seo, Hyuk-Soo, Ohguchi, Hiroto, Samur, Mehmet K., Cirstea, Diana, Mimura, Naoya, Iwasawa, Yoshikazu, Richardson, Paul G., Munshi, Nikhil C., Chauhan, Dharminder, Massefski, Walter, Utsugi, Teruhiro, Dhe-Paganon, Sirano, Anderson, Kenneth C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2017
Soggetti:
Lymphoid Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5345734/
https://ncbi.nlm.nih.gov/pubmed/28082445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-09-738500
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