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The Potential Role of Lysosomal Sequestration in Sunitinib Resistance of Renal Cell Cancer

Renal cell carcinoma (RCC) is a highly vascularized tumor type, which is often associated with inactivated mutations in the von Hippel-Lindau gene that drives proangiogenic signaling pathways. As such, new therapies for the treatment of RCC have largely been focused on blocking angiogenesis. Sunitin...

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Detalhes bibliográficos
Publicado no:J Kidney Cancer VHL
Main Authors: Azijli, Kaamar, Gotink, Kristy J., Verheul, Henk M.W.
Formato: Artigo
Idioma:Inglês
Publicado em: Codon Publications 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5345522/
https://ncbi.nlm.nih.gov/pubmed/28326274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15586/jkcvhl.2015.44
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