Lysosomal Sequestration of Sunitinib: A Novel Mechanism of Drug Resistance

PURPOSE: Resistance to antiangiogenic tyrosine kinase inhibitors such as sunitinib is an important clinical problem, but its underlying mechanisms are largely unknown. We analyzed tumor sunitinib levels in mice and patients and studied sensitivity and resistance mechanisms to sunitinib. EXPERIMENTAL...

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Publicat a:Clin Cancer Res
Autors principals: Gotink, Kristy J., Broxterman, Henk J., Labots, Mariette, de Haas, Richard R., Dekker, Henk, Honeywell, Richard J., Rudek, Michelle A., Beerepoot, Laurens V., Musters, René J., Jansen, Gerrit, Griffioen, Arjan W., Assaraf, Yehuda G., Pili, Roberto, Peters, Godefridus J., Verheul, Henk M.W.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4461037/
https://ncbi.nlm.nih.gov/pubmed/21980135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-1667
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