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Lysosomal Sequestration of Sunitinib: A Novel Mechanism of Drug Resistance
PURPOSE: Resistance to antiangiogenic tyrosine kinase inhibitors such as sunitinib is an important clinical problem, but its underlying mechanisms are largely unknown. We analyzed tumor sunitinib levels in mice and patients and studied sensitivity and resistance mechanisms to sunitinib. EXPERIMENTAL...
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發表在: | Clin Cancer Res |
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Main Authors: | , , , , , , , , , , , , , , |
格式: | Artigo |
語言: | Inglês |
出版: |
2011
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主題: | |
在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4461037/ https://ncbi.nlm.nih.gov/pubmed/21980135 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-1667 |
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