Lysosomal Sequestration of Sunitinib: A Novel Mechanism of Drug Resistance

PURPOSE: Resistance to antiangiogenic tyrosine kinase inhibitors such as sunitinib is an important clinical problem, but its underlying mechanisms are largely unknown. We analyzed tumor sunitinib levels in mice and patients and studied sensitivity and resistance mechanisms to sunitinib. EXPERIMENTAL...

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Опубликовано в: :Clin Cancer Res
Главные авторы: Gotink, Kristy J., Broxterman, Henk J., Labots, Mariette, de Haas, Richard R., Dekker, Henk, Honeywell, Richard J., Rudek, Michelle A., Beerepoot, Laurens V., Musters, René J., Jansen, Gerrit, Griffioen, Arjan W., Assaraf, Yehuda G., Pili, Roberto, Peters, Godefridus J., Verheul, Henk M.W.
Формат: Artigo
Язык:Inglês
Опубликовано: 2011
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4461037/
https://ncbi.nlm.nih.gov/pubmed/21980135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-1667
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