The dynamic DNA methylation landscape of the mutL homolog 1 shore is altered by MLH1-93G>A polymorphism in normal tissues and colorectal cancer

BACKGROUND: Colorectal cancers (CRCs) undergo distinct genetic and epigenetic alterations. Expression of mutL homolog 1 (MLH1), a mismatch repair gene that corrects DNA replication errors, is lost in up to 15% of sporadic tumours due to mutation or, more commonly, due to DNA methylation of its promo...

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Bibliographic Details
Published in:Clin Epigenetics
Main Authors: Savio, Andrea J., Mrkonjic, Miralem, Lemire, Mathieu, Gallinger, Steven, Knight, Julia A., Bapat, Bharat
Format: Artigo
Language:Inglês
Published: BioMed Central 2017
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5345264/
https://ncbi.nlm.nih.gov/pubmed/28293327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-017-0326-6
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