CD117(+)CD44(+) Stem T Cells Develop in the Thymus and Potently Suppress T-cell Proliferation by Modulating the CTLA-4 Pathway

BACKGROUND: CD117 is expressed on double-negative (DN; CD4(–)CD8(–)) cells (Nat Rev Immunol 14:529–545; 2014), but whether it is expressed in other stages and its subsequent functions are unclear. We used an improved method of flow cytometry to analyze different populations of thymocytes (Sci Rep 4:...

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Dettagli Bibliografici
Pubblicato in:Stem Cell Res Ther
Autori principali: Wei, Yang, Hu, Zhansheng, Gu, Wen, Liu, Gang, Shi, Bingyin, Liu, Enqi, Liu, Tie
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2017
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5345162/
https://ncbi.nlm.nih.gov/pubmed/28279199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-017-0495-4
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