Estrogen prevents bone loss through transforming growth factor β signaling in T cells

Estrogen (E) deficiency leads to an expansion of the pool of tumor necrosis factor (TNF)-producing T cells through an IFN-γ-dependent pathway that results in increased levels of the osteoclastogenic cytokine TNF in the bone marrow. Disregulated IFN-γ production is instrumental for the bone loss indu...

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Detalhes bibliográficos
Main Authors: Gao, Yuhao, Qian, Wei-Ping, Dark, Kimberly, Toraldo, Gianluca, Lin, Angela S. P., Guldberg, Robert E., Flavell, Richard A., Weitzmann, M. Neale, Pacifici, Roberto
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC534514/
https://ncbi.nlm.nih.gov/pubmed/15531637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0404888101
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