Prevalence of NRAS, PTEN and AKT1 gene mutations in the central nervous system metastases of non-small cell lung cancer

Somatic mutations in NRAS, PTEN and AKT1 genes are rarely (~1%) reported in primary NSCLC, but their role in carcinogenesis have been proven. Therefore, we assessed the frequency of them in 145 FFPE tissue samples from CNS metastases of NSCLC using the real-time PCR technique. We identified four (tw...

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Bibliographic Details
Published in:Brain Tumor Pathol
Main Authors: Nicoś, Marcin, Krawczyk, Paweł, Jarosz, Bożena, Sawicki, Marek, Trojanowski, Tomasz, Milanowski, Janusz
Format: Artigo
Language:Inglês
Published: Springer Japan 2017
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5344951/
https://ncbi.nlm.nih.gov/pubmed/28097440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10014-016-0276-2
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