Prevalence of NRAS, PTEN and AKT1 gene mutations in the central nervous system metastases of non-small cell lung cancer

Somatic mutations in NRAS, PTEN and AKT1 genes are rarely (~1%) reported in primary NSCLC, but their role in carcinogenesis have been proven. Therefore, we assessed the frequency of them in 145 FFPE tissue samples from CNS metastases of NSCLC using the real-time PCR technique. We identified four (tw...

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Enregistré dans:
Détails bibliographiques
Publié dans:Brain Tumor Pathol
Auteurs principaux: Nicoś, Marcin, Krawczyk, Paweł, Jarosz, Bożena, Sawicki, Marek, Trojanowski, Tomasz, Milanowski, Janusz
Format: Artigo
Langue:Inglês
Publié: Springer Japan 2017
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5344951/
https://ncbi.nlm.nih.gov/pubmed/28097440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10014-016-0276-2
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