The Application of Real-Time PCR Technique to Detect Rare Cell Clones with Primary T790M Substitution of EGFR Gene in Metastases of Non-small Cell Lung Cancer to Central Nervous System in Chemotherapy Naive Patients

The time-limited efficacy of reversible EGFR-TKIs in patients with advanced non-small cell lung cancer (NSCLC) with EGFR gene activating mutations is associated with development of treatment resistance after some period of therapy. This resistance predominantly results from secondary mutations locat...

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Detalhes bibliográficos
Main Authors: Powrózek, Tomasz, Krawczyk, Paweł, Jarosz, Bożena, Mlak, Radosław, Wojas-Krawczyk, Kamila, Sawicki, Marek, Stencel, Dariusz, Trojanowski, Tomasz, Milanowski, Janusz
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Netherlands 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4177043/
https://ncbi.nlm.nih.gov/pubmed/24789720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12253-014-9778-6
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