Mechanisms of resistance to reversible inhibitors of EGFR tyrosine kinase in non-small cell lung cancer

Abnormalities of epidermal growth factor receptor (EGFR) in non-small-cell lung cancer (NSCLC) patients consist of EGFR overexpression and EGFR (HER1) gene mutations. Structural dysfunction of the tyrosine kinase domain of EGFR is associated with the clinical response to tyrosine kinase inhibitors (...

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Detalhes bibliográficos
Main Authors: Krawczyk, Paweł, Mlak, Radosław, Powrózek, Tomasz, Nicoś, Marcin, Kowalski, Dariusz M., Wojas-Krawczyk, Kamila, Milanowski, Janusz
Formato: Artigo
Idioma:Inglês
Publicado em: Termedia Publishing House 2012
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3687444/
https://ncbi.nlm.nih.gov/pubmed/23788917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5114/wo.2012.31768
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