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Mechanisms of resistance to reversible inhibitors of EGFR tyrosine kinase in non-small cell lung cancer

Abnormalities of epidermal growth factor receptor (EGFR) in non-small-cell lung cancer (NSCLC) patients consist of EGFR overexpression and EGFR (HER1) gene mutations. Structural dysfunction of the tyrosine kinase domain of EGFR is associated with the clinical response to tyrosine kinase inhibitors (...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Krawczyk, Paweł, Mlak, Radosław, Powrózek, Tomasz, Nicoś, Marcin, Kowalski, Dariusz M., Wojas-Krawczyk, Kamila, Milanowski, Janusz
Format: Artigo
Sprache:Inglês
Veröffentlicht: Termedia Publishing House 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3687444/
https://ncbi.nlm.nih.gov/pubmed/23788917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5114/wo.2012.31768
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