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Mechanisms of resistance to reversible inhibitors of EGFR tyrosine kinase in non-small cell lung cancer
Abnormalities of epidermal growth factor receptor (EGFR) in non-small-cell lung cancer (NSCLC) patients consist of EGFR overexpression and EGFR (HER1) gene mutations. Structural dysfunction of the tyrosine kinase domain of EGFR is associated with the clinical response to tyrosine kinase inhibitors (...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Termedia Publishing House
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3687444/ https://ncbi.nlm.nih.gov/pubmed/23788917 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5114/wo.2012.31768 |
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