Methylation level of CpG islands in GGH gene promoter in pediatric acute leukemia

BACKGROUND: γ-Glutamyl hydrolase (GGH) regulates intracellular folates and antifolates such as methotrexate (MTX) for proper nucleotide biosynthesis and antifolate-induced cytotoxicity, respectively. In addition to genetic polymorphism and karyotypic abnormalities, methylation of CpG island 1 (CpG1)...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Li, Yue, Liu, Sixi, Wang, Huihui, Mai, Huirong, Yuan, Xiuli, Li, Changgang, Chen, Xiaowen, Wen, Feiqiu
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2017
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5344458/
https://ncbi.nlm.nih.gov/pubmed/28278270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0173472
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