Methylation level of CpG islands in GGH gene promoter in pediatric acute leukemia

BACKGROUND: γ-Glutamyl hydrolase (GGH) regulates intracellular folates and antifolates such as methotrexate (MTX) for proper nucleotide biosynthesis and antifolate-induced cytotoxicity, respectively. In addition to genetic polymorphism and karyotypic abnormalities, methylation of CpG island 1 (CpG1)...

Full description

Saved in:
Bibliographic Details
Published in:PLoS One
Main Authors: Li, Yue, Liu, Sixi, Wang, Huihui, Mai, Huirong, Yuan, Xiuli, Li, Changgang, Chen, Xiaowen, Wen, Feiqiu
Format: Artigo
Language:Inglês
Published: Public Library of Science 2017
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5344458/
https://ncbi.nlm.nih.gov/pubmed/28278270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0173472
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items