Double-stranded RNA promotes CTL-independent tumor cytolysis mediated by CD11b(+)Ly6G(+) intratumor myeloid cells through the TICAM-1 signaling pathway

PolyI:C, a synthetic double-stranded RNA analog, acts as an immune-enhancing adjuvant that regresses tumors in cytotoxic T lymphocyte (CTL)-dependent and CTL-independent manner, the latter of which remains largely unknown. Tumors contain CD11b(+)Ly6G(+) cells, known as granulocytic myeloid-derived s...

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Detalles Bibliográficos
Publicado en:Cell Death Differ
Main Authors: Shime, Hiroaki, Matsumoto, Misako, Seya, Tsukasa
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2017
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Original Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5344202/
https://ncbi.nlm.nih.gov/pubmed/27834952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2016.131
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