Rational design of low immunogenic anti CD25 recombinant immunotoxin for T cell malignancies by elimination of T cell epitopes in PE38

LMB-2, is a potent recombinant immunotoxin (RIT) that is composed of scFv antibody that targets CD25 (Tac) and a toxin fragment (PE38). It is used to treat T cell leukemias and lymphomas. To make LMB-2 less immunogenic, we introduced a large deletion in domain II and six point mutations in domain II...

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Pubblicato in:Cell Immunol
Autori principali: Mazor, Ronit, Kaplan, Gilad, Park, Dong, Jang, Youjin, Lee, Fred, Kreitman, Robert, Pastan, Ira
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5344129/
https://ncbi.nlm.nih.gov/pubmed/28087047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellimm.2017.01.003
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