Human Brain Imaging of α7 nAChR with [(18)F]ASEM: a New PET Radiotracer for Neuropsychiatry and Determination of Drug Occupancy

PURPOSE: Using the α7-nAChR radiotracer, [(18)F]ASEM, we present the first successful human positron emission tomography (PET) studies. Rodent occupancy with three clinically employed α7-nAChR drugs confirms the specificity of the radiotracer. PROCEDURES: Five healthy male subjects were imaged for 9...

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Udgivet i:Mol Imaging Biol
Main Authors: Wong, Dean F., Kuwabara, Hiroto, Pomper, Martin, Holt, Daniel P., Brasic, James R., George, Noble, Frolov, Boris, Willis, William, Gao, Yongjun, Valentine, Heather, Nandi, Ayon, Gapasin, Lorena, Dannals, Robert F., Horti, Andrew G.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5344036/
https://ncbi.nlm.nih.gov/pubmed/25145965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11307-014-0779-3
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