Cytochrome P450s in human immune cells regulate IL-22 and c-Kit via an AHR feedback loop

The mechanisms how environmental compounds influence the human immune system are unknown. The environmentally sensitive transcription factor aryl hydrocarbon receptor (AHR) has immune-modulating functions and responds to small molecules. Cytochrome P4501 enzymes (CYP1) act downstream of the AHR and...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Effner, Renate, Hiller, Julia, Eyerich, Stefanie, Traidl-Hoffmann, Claudia, Brockow, Knut, Triggiani, Massimo, Behrendt, Heidrun, Schmidt-Weber, Carsten B., Buters, Jeroen T. M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5343665/
https://ncbi.nlm.nih.gov/pubmed/28276465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44005
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