Alternative exon skipping biases substrate preference of the deubiquitylase USP15 for mysterin/RNF213, the moyamoya disease susceptibility factor

The deubiquitylating enzyme USP15 plays significant roles in multiple cellular pathways including TGF-β signaling, RNA splicing, and innate immunity. Evolutionarily conserved skipping of exon 7 occurs during transcription of the mRNAs encoding USP15 and its paralogue USP4, yielding two major isoform...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Kotani, Yuri, Morito, Daisuke, Sakata, Kenshiro, Ainuki, Shiori, Sugihara, Munechika, Hatta, Tomohisa, Iemura, Shun-ichiro, Takashima, Seiji, Natsume, Tohru, Nagata, Kazuhiro
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5343593/
https://ncbi.nlm.nih.gov/pubmed/28276505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44293
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