High-Throughput Simulations Reveal Membrane-Mediated Effects of Alcohols on MscL Gating

[Image: see text] The mechanosensitive channels of large conductance (MscL) are bacterial membrane proteins that serve as last resort emergency release valves in case of severe osmotic downshock. Sensing bilayer tension, MscL channels are sensitive to changes in the bilayer environment and are, ther...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Melo, Manuel N., Arnarez, Clément, Sikkema, Hendrik, Kumar, Neeraj, Walko, Martin, Berendsen, Herman J. C., Kocer, Armagan, Marrink, Siewert J., Ingólfsson, Helgi I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2017
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5343553/
https://ncbi.nlm.nih.gov/pubmed/28122455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b11091
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