High-Throughput Simulations Reveal Membrane-Mediated Effects of Alcohols on MscL Gating

[Image: see text] The mechanosensitive channels of large conductance (MscL) are bacterial membrane proteins that serve as last resort emergency release valves in case of severe osmotic downshock. Sensing bilayer tension, MscL channels are sensitive to changes in the bilayer environment and are, ther...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Am Chem Soc
Prif Awduron: Melo, Manuel N., Arnarez, Clément, Sikkema, Hendrik, Kumar, Neeraj, Walko, Martin, Berendsen, Herman J. C., Kocer, Armagan, Marrink, Siewert J., Ingólfsson, Helgi I.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Chemical Society 2017
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5343553/
https://ncbi.nlm.nih.gov/pubmed/28122455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b11091
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