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High-Throughput Simulations Reveal Membrane-Mediated Effects of Alcohols on MscL Gating

[Image: see text] The mechanosensitive channels of large conductance (MscL) are bacterial membrane proteins that serve as last resort emergency release valves in case of severe osmotic downshock. Sensing bilayer tension, MscL channels are sensitive to changes in the bilayer environment and are, ther...

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書目詳細資料
發表在:J Am Chem Soc
Main Authors: Melo, Manuel N., Arnarez, Clément, Sikkema, Hendrik, Kumar, Neeraj, Walko, Martin, Berendsen, Herman J. C., Kocer, Armagan, Marrink, Siewert J., Ingólfsson, Helgi I.
格式: Artigo
語言:Inglês
出版: American Chemical Society 2017
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5343553/
https://ncbi.nlm.nih.gov/pubmed/28122455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b11091
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