Ran GTPase promotes cancer progression via Met receptor-mediated downstream signaling

It has been shown previously that cancer cells with an activated oncogenic pathway, including Met activation, require Ran for growth and survival. Here, we show that knockdown of Ran leads to a reduction of Met receptor expression in several breast and lung cancer cell lines. This, in turn suppresse...

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Detalles Bibliográficos
Publicado en:Oncotarget
Main Authors: Yuen, Hiu-Fung, Chan, Ka-Kui, Platt-Higgins, Angela, Dakir, El-Habib, Matchett, Kyle B., Haggag, Yusuf Ahmed, Jithesh, Puthen V., Habib, Tanwir, Faheem, Ahmed, Dean, Fennell A., Morgan, Richard, Rudland, Philip S., El-Tanani, Mohamed
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2016
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342783/
https://ncbi.nlm.nih.gov/pubmed/27716616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12420
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