Ran GTPase promotes cancer progression via Met receptor-mediated downstream signaling

It has been shown previously that cancer cells with an activated oncogenic pathway, including Met activation, require Ran for growth and survival. Here, we show that knockdown of Ran leads to a reduction of Met receptor expression in several breast and lung cancer cell lines. This, in turn suppresse...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Yuen, Hiu-Fung, Chan, Ka-Kui, Platt-Higgins, Angela, Dakir, El-Habib, Matchett, Kyle B., Haggag, Yusuf Ahmed, Jithesh, Puthen V., Habib, Tanwir, Faheem, Ahmed, Dean, Fennell A., Morgan, Richard, Rudland, Philip S., El-Tanani, Mohamed
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342783/
https://ncbi.nlm.nih.gov/pubmed/27716616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12420
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