PEITC-mediated inhibition of mRNA translation is associated with both inhibition of mTORC1 and increased eIF2α phosphorylation in established cell lines and primary human leukemia cells

Increased mRNA translation drives carcinogenesis and is an attractive target for the development of new anti-cancer drugs. In this work, we investigated effects of phenethylisothiocyanate (PEITC), a phytochemical with chemopreventive and anti-cancer activity, on mRNA translation. PEITC rapidly inhib...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Yeomans, Alison, Lemm, Elizabeth, Wilmore, Sarah, Cavell, Breeze E., Valle-Argos, Beatriz, Krysov, Sergey, Hidalgo, Marina Sanchez, Leonard, Elodie, Willis, Anne E., Forconi, Francesco, Stevenson, Freda K., Steele, Andrew J., Coldwell, Mark J., Packham, Graham
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342703/
https://ncbi.nlm.nih.gov/pubmed/27579538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11655
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