LYRM03, an ubenimex derivative, attenuates LPS-induced acute lung injury in mice by suppressing the TLR4 signaling pathway

Toll-like receptor 4 (TLR4)-mediated signaling plays a critical role in sepsis-induced acute lung injury (ALI). LYRM03 (3-amino-2-hydroxy-4-phenyl-valyl-isoleucine) is a novel derivative of ubenimex, a widely used antineoplastic medicine. We previously found that LYRM03 has anti-inflammatory effects...

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Detalhes bibliográficos
Publicado no:Acta Pharmacol Sin
Main Authors: He, Hui-qiong, Wu, Ya-xian, Nie, Yun-juan, Wang, Jun, Ge, Mei, Qian, Feng
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342666/
https://ncbi.nlm.nih.gov/pubmed/28112185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2016.141
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