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Engagement of CD44 by hyaluronan suppresses TLR4 signaling and the septic response to LPS
Fragments of hyaluronan released after injury bind and activate TLR4 in a complex with CD44. Here we investigated if the recognition of hyaluronan by CD44 and TLR4 alters lipopolysaccaride (LPS) responsiveness and thus could alter the septic response. In contrast to mice injected with LPS, mice expo...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2787860/ https://ncbi.nlm.nih.gov/pubmed/19781786 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2009.08.026 |
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