SMAD4 loss enables EGF, TGFβ1 and S100A8/A9 induced activation of critical pathways to invasion in human pancreatic adenocarcinoma cells

Epidermal Growth Factor (EGF) receptor overexpression, KRAS, TP53, CDKN2A and SMAD4 mutations characterize pancreatic ductal adenocarcinoma. This mutational landscape might influence cancer cells response to EGF, Transforming Growth Factor β1 (TGFβ1) and stromal inflammatory calcium binding proteins...

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Dades bibliogràfiques
Publicat a:Oncotarget
Autors principals: Moz, Stefania, Basso, Daniela, Bozzato, Dania, Galozzi, Paola, Navaglia, Filippo, Negm, Ola H., Arrigoni, Giorgio, Zambon, Carlo-Federico, Padoan, Andrea, Tighe, Paddy, Todd, Ian, Franchin, Cinzia, Pedrazzoli, Sergio, Punzi, Leonardo, Plebani, Mario
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2016
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342525/
https://ncbi.nlm.nih.gov/pubmed/27655713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12068
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