PDAC-derived exosomes enrich the microenvironment in MDSCs in a SMAD4-dependent manner through a new calcium related axis

Tumor genetics and escape from immune surveillance concur in the poor prognosis of PDAC. In this study an experimental model was set up to verify whether SMAD4, deleted in about 55% PDAC and associated with poor prognosis, is involved in determining immunosuppression through Exosomes (Exo). Potentia...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Basso, Daniela, Gnatta, Elisa, Padoan, Andrea, Fogar, Paola, Furlanello, Sara, Aita, Ada, Bozzato, Dania, Zambon, Carlo-Federico, Arrigoni, Giorgio, Frasson, Chiara, Franchin, Cinzia, Moz, Stefania, Brefort, Thomas, Laufer, Thomas, Navaglia, Filippo, Pedrazzoli, Sergio, Basso, Giuseppe, Plebani, Mario
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5689584/
https://ncbi.nlm.nih.gov/pubmed/29156694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.20863
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