PDAC-derived exosomes enrich the microenvironment in MDSCs in a SMAD4-dependent manner through a new calcium related axis

Tumor genetics and escape from immune surveillance concur in the poor prognosis of PDAC. In this study an experimental model was set up to verify whether SMAD4, deleted in about 55% PDAC and associated with poor prognosis, is involved in determining immunosuppression through Exosomes (Exo). Potentia...

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Vydáno v:Oncotarget
Hlavní autoři: Basso, Daniela, Gnatta, Elisa, Padoan, Andrea, Fogar, Paola, Furlanello, Sara, Aita, Ada, Bozzato, Dania, Zambon, Carlo-Federico, Arrigoni, Giorgio, Frasson, Chiara, Franchin, Cinzia, Moz, Stefania, Brefort, Thomas, Laufer, Thomas, Navaglia, Filippo, Pedrazzoli, Sergio, Basso, Giuseppe, Plebani, Mario
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5689584/
https://ncbi.nlm.nih.gov/pubmed/29156694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.20863
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