PDAC-derived exosomes enrich the microenvironment in MDSCs in a SMAD4-dependent manner through a new calcium related axis

Tumor genetics and escape from immune surveillance concur in the poor prognosis of PDAC. In this study an experimental model was set up to verify whether SMAD4, deleted in about 55% PDAC and associated with poor prognosis, is involved in determining immunosuppression through Exosomes (Exo). Potentia...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Basso, Daniela, Gnatta, Elisa, Padoan, Andrea, Fogar, Paola, Furlanello, Sara, Aita, Ada, Bozzato, Dania, Zambon, Carlo-Federico, Arrigoni, Giorgio, Frasson, Chiara, Franchin, Cinzia, Moz, Stefania, Brefort, Thomas, Laufer, Thomas, Navaglia, Filippo, Pedrazzoli, Sergio, Basso, Giuseppe, Plebani, Mario
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5689584/
https://ncbi.nlm.nih.gov/pubmed/29156694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.20863
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