PDAC-derived exosomes enrich the microenvironment in MDSCs in a SMAD4-dependent manner through a new calcium related axis

Tumor genetics and escape from immune surveillance concur in the poor prognosis of PDAC. In this study an experimental model was set up to verify whether SMAD4, deleted in about 55% PDAC and associated with poor prognosis, is involved in determining immunosuppression through Exosomes (Exo). Potentia...

詳細記述

保存先:
書誌詳細
出版年:Oncotarget
主要な著者: Basso, Daniela, Gnatta, Elisa, Padoan, Andrea, Fogar, Paola, Furlanello, Sara, Aita, Ada, Bozzato, Dania, Zambon, Carlo-Federico, Arrigoni, Giorgio, Frasson, Chiara, Franchin, Cinzia, Moz, Stefania, Brefort, Thomas, Laufer, Thomas, Navaglia, Filippo, Pedrazzoli, Sergio, Basso, Giuseppe, Plebani, Mario
フォーマット: Artigo
言語:Inglês
出版事項: Impact Journals LLC 2017
主題:
Research Paper
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5689584/
https://ncbi.nlm.nih.gov/pubmed/29156694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.20863
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