SMAD4 loss enables EGF, TGFβ1 and S100A8/A9 induced activation of critical pathways to invasion in human pancreatic adenocarcinoma cells

Epidermal Growth Factor (EGF) receptor overexpression, KRAS, TP53, CDKN2A and SMAD4 mutations characterize pancreatic ductal adenocarcinoma. This mutational landscape might influence cancer cells response to EGF, Transforming Growth Factor β1 (TGFβ1) and stromal inflammatory calcium binding proteins...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Moz, Stefania, Basso, Daniela, Bozzato, Dania, Galozzi, Paola, Navaglia, Filippo, Negm, Ola H., Arrigoni, Giorgio, Zambon, Carlo-Federico, Padoan, Andrea, Tighe, Paddy, Todd, Ian, Franchin, Cinzia, Pedrazzoli, Sergio, Punzi, Leonardo, Plebani, Mario
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342525/
https://ncbi.nlm.nih.gov/pubmed/27655713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12068
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