Fibroblast growth factor 23 dysregulates late sodium current and calcium homeostasis with enhanced arrhythmogenesis in pulmonary vein cardiomyocytes

Fibroblast growth factor 23 (FGF23), elevated in chronic renal failure, increases atrial arrhythmogenesis and dysregulates calcium homeostasis. Late sodium currents (I(Na-Late)) critically induces ectopic activity of pulmoanry vein (the most important atrial fibrillation trigger). This study was to...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Huang, Shih-Yu, Chen, Yao-Chang, Kao, Yu-Hsun, Hsieh, Ming-Hsiung, Lin, Yung-Kuo, Chung, Cheng-Chih, Lee, Ting-I, Tsai, Wen-Chin, Chen, Shih-Ann, Chen, Yi-Jen
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper: Pathology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342473/
https://ncbi.nlm.nih.gov/pubmed/27713141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12470
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