RGS6 is an essential tumor suppressor that prevents bladder carcinogenesis by promoting p53 activation and DNMT1 downregulation

Urinary bladder cancer (UBC) is largely caused by exposure to toxic chemicals including those in cigarette smoke (i.e. BBN). An activating SNP in RGS6 is associated with a pronounced reduction in UBC risk, especially among smokers. However, the mechanism underlying this reduction remains unknown. He...

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Dades bibliogràfiques
Publicat a:Oncotarget
Autors principals: Yang, Jianqi, Platt, Lance T., Maity, Biswanath, Ahlers, Katelin E., Luo, Zili, Lin, Zhibo, Chakravarti, Bandana, Ibeawuchi, Stella-Rita, Askeland, Ryan W., Bondaruk, Jolanta, Czerniak, Bogdan A., Fisher, Rory A.
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2016
Matèries:
Priority Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342467/
https://ncbi.nlm.nih.gov/pubmed/27713144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12473
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