RGS6 Suppresses Ras-induced Cellular Transformation by Facilitating Tip60-mediated Dnmt1 Degradation and Promoting Apoptosis

The RAS protooncogene plays a central role in regulation of cell proliferation, and point mutations leading to oncogenic activation of Ras occur in a large number of human cancers. Silencing of tumor suppressor genes by DNA methyltransferase 1 (Dnmt1) is essential for oncogenic cellular transformati...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:Oncogene
Hoofdauteurs: Huang, Jie, Stewart, Adele, Maity, Biswanath, Hagen, Jussara, Fagan, Rebecca L., Yang, Jianqi, Quelle, Dawn E., Brenner, Charles, Fisher, Rory A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2013
Onderwerpen:
Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4232305/
https://ncbi.nlm.nih.gov/pubmed/23995786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.324
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items