The trans-membrane domain of Bcl-2α, but not its hydrophobic cleft, is a critical determinant for efficient IP(3) receptor inhibition

The anti-apoptotic Bcl-2 protein is emerging as an efficient inhibitor of IP(3)R function, contributing to its oncogenic properties. Yet, the underlying molecular mechanisms remain not fully understood. Using mutations or pharmacological inhibition to antagonize Bcl-2's hydrophobic cleft, we ex...

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Detaylı Bibliyografya
Yayımlandı:Oncotarget
Asıl Yazarlar: Ivanova, Hristina, Ritaine, Abigael, Wagner, Larry, Luyten, Tomas, Shapovalov, George, Welkenhuyzen, Kirsten, Seitaj, Bruno, Monaco, Giovanni, De Smedt, Humbert, Prevarskaya, Natalia, Yule, David I., Parys, Jan B., Bultynck, Geert
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Impact Journals LLC 2016
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342447/
https://ncbi.nlm.nih.gov/pubmed/27494888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11005
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