Artificial small RNA for sequence specific cleavage of target RNA through RNase III endonuclease Dicer

CRISPR-Cas9 system uses a guide RNA which functions in conjunction with Cas9 proteins to target a DNA and cleaves double-strand DNA. This phenomenon raises a question whether an artificial small RNA (asRNA), composed of a Dicer–binding RNA element and an antisense RNA, could also be used to induce D...

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Udgivet i:Oncotarget
Main Authors: Xu, Wen, Liu, Yuchen, Liu, Yali, Liu, Li, Zhan, Yonghao, Zhuang, Chengle, Lin, Junhao, Chen, Mingwei, Li, Jianfa, Cai, Zhiming, Huang, Weiren, Zhang, Yong
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342362/
https://ncbi.nlm.nih.gov/pubmed/27231846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9582
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