Elevated level of Interleukin-35 in colorectal cancer induces conversion of T cells into iTr35 by activating STAT1/STAT3

IL-35 is a novel heterodimeric and inhibitory cytokine, composed of interleukin-12 subunit alpha (P35) and Epstein-Barr virus -induced gene 3 (EBI3). IL-35 has been reported to be produced by a range of cell types, especially regulatory T cells, and to exert immunosuppressive effects via the STATx s...

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Pubblicato in:Oncotarget
Autori principali: Ma, Yanhui, Chen, Lei, Xie, Guohua, Zhou, Yunlan, Yue, Chaoyan, Yuan, Xiangliang, Zheng, Yingxia, Wang, Weiwei, Deng, Lin, Shen, Lisong
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2016
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5341959/
https://ncbi.nlm.nih.gov/pubmed/27682874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12193
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