Janus and PI3-kinases mediate glucocorticoid resistance in activated chronic leukemia cells

Glucorticoids (GCs) such as dexamethasone (DEX) remain important treatments for Chronic Lymphocytic Leukemia (CLL) but the mechanisms are poorly understood and resistance is inevitable. Proliferation centers (PC) in lymph nodes and bone marrow offer protection against many cytotoxic drugs and circul...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Oppermann, Sina, Lam, Avery J., Tung, Stephanie, Shi, Yonghong, McCaw, Lindsay, Wang, Guizhei, Ylanko, Jarkko, Leber, Brian, Andrews, David, Spaner, David E.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5341931/
https://ncbi.nlm.nih.gov/pubmed/27579615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11618
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