Clinical and kinomic analysis identifies peripheral blood mononuclear cells as a potential pharmacodynamic biomarker in metastatic renal cell carcinoma patients treated with sunitinib

BACKGROUND: Sunitinib is a protein tyrosine kinase (PTK) inhibitor that has immune-modulating properties. In this context, peripheral blood mononuclear cells (PBMC), mainly constituted by lymphocytes, could be a perfect surrogate tissue for identifying and assaying pharmacodynamic biomarkers of suni...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Oncotarget
Main Authors: Noé, Gaёlle, Bellesoeur, Audrey, Thomas-Schoemann, Audrey, Rangarajan, Savithri, Naji, Faris, Puszkiel, Alicja, Huillard, Olivier, Saidu, Nathaniel, Golmard, Lisa, Alexandre, Jerome, Goldwasser, Francois, Blanchet, Benoit, Vidal, Michel
פורמט: Artigo
שפה:Inglês
יצא לאור: Impact Journals LLC 2016
נושאים:
Clinical Research Paper
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5341893/
https://ncbi.nlm.nih.gov/pubmed/27589830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11686
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