Clinical and kinomic analysis identifies peripheral blood mononuclear cells as a potential pharmacodynamic biomarker in metastatic renal cell carcinoma patients treated with sunitinib

BACKGROUND: Sunitinib is a protein tyrosine kinase (PTK) inhibitor that has immune-modulating properties. In this context, peripheral blood mononuclear cells (PBMC), mainly constituted by lymphocytes, could be a perfect surrogate tissue for identifying and assaying pharmacodynamic biomarkers of suni...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Noé, Gaёlle, Bellesoeur, Audrey, Thomas-Schoemann, Audrey, Rangarajan, Savithri, Naji, Faris, Puszkiel, Alicja, Huillard, Olivier, Saidu, Nathaniel, Golmard, Lisa, Alexandre, Jerome, Goldwasser, Francois, Blanchet, Benoit, Vidal, Michel
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Clinical Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5341893/
https://ncbi.nlm.nih.gov/pubmed/27589830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11686
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