Blockade efficacy of MEK/ERK-dependent autophagy enhances PI3K/Akt inhibitor NVP-BKM120's therapeutic effectiveness in lung cancer cells

NVP-BKM120 (BKM120) is a new pan-class I phosphatidylinositol-3 kinase (PI3K) inhibitor and has been tested in clinical trials as an anticancer agent. In this study, we determined whether BKM120 induces autophagy and the impact of autophagy induction on BKM120's growth-inhibitory activity. BKM1...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Ren, Hui, Guo, Hua, Thakur, Asmitananda, Zhang, Shuo, Wang, Ting, Liang, Yiqian, Shi, Puyu, Gao, Lei, Liu, Feng, Feng, Jing, Chen, Tianjun, Yang, Tian, Shang, Dong, Liu, Johnson J., Xu, Feng, Chen, Mingwei
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2016
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5341874/
https://ncbi.nlm.nih.gov/pubmed/27572309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11645
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