Blockade efficacy of MEK/ERK-dependent autophagy enhances PI3K/Akt inhibitor NVP-BKM120's therapeutic effectiveness in lung cancer cells

NVP-BKM120 (BKM120) is a new pan-class I phosphatidylinositol-3 kinase (PI3K) inhibitor and has been tested in clinical trials as an anticancer agent. In this study, we determined whether BKM120 induces autophagy and the impact of autophagy induction on BKM120's growth-inhibitory activity. BKM1...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Ren, Hui, Guo, Hua, Thakur, Asmitananda, Zhang, Shuo, Wang, Ting, Liang, Yiqian, Shi, Puyu, Gao, Lei, Liu, Feng, Feng, Jing, Chen, Tianjun, Yang, Tian, Shang, Dong, Liu, Johnson J., Xu, Feng, Chen, Mingwei
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5341874/
https://ncbi.nlm.nih.gov/pubmed/27572309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11645
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