Blockade efficacy of MEK/ERK-dependent autophagy enhances PI3K/Akt inhibitor NVP-BKM120's therapeutic effectiveness in lung cancer cells

NVP-BKM120 (BKM120) is a new pan-class I phosphatidylinositol-3 kinase (PI3K) inhibitor and has been tested in clinical trials as an anticancer agent. In this study, we determined whether BKM120 induces autophagy and the impact of autophagy induction on BKM120's growth-inhibitory activity. BKM1...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Ren, Hui, Guo, Hua, Thakur, Asmitananda, Zhang, Shuo, Wang, Ting, Liang, Yiqian, Shi, Puyu, Gao, Lei, Liu, Feng, Feng, Jing, Chen, Tianjun, Yang, Tian, Shang, Dong, Liu, Johnson J., Xu, Feng, Chen, Mingwei
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5341874/
https://ncbi.nlm.nih.gov/pubmed/27572309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11645
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados