Blockade efficacy of MEK/ERK-dependent autophagy enhances PI3K/Akt inhibitor NVP-BKM120's therapeutic effectiveness in lung cancer cells

NVP-BKM120 (BKM120) is a new pan-class I phosphatidylinositol-3 kinase (PI3K) inhibitor and has been tested in clinical trials as an anticancer agent. In this study, we determined whether BKM120 induces autophagy and the impact of autophagy induction on BKM120's growth-inhibitory activity. BKM1...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Oncotarget
Prif Awduron: Ren, Hui, Guo, Hua, Thakur, Asmitananda, Zhang, Shuo, Wang, Ting, Liang, Yiqian, Shi, Puyu, Gao, Lei, Liu, Feng, Feng, Jing, Chen, Tianjun, Yang, Tian, Shang, Dong, Liu, Johnson J., Xu, Feng, Chen, Mingwei
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Impact Journals LLC 2016
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5341874/
https://ncbi.nlm.nih.gov/pubmed/27572309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11645
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