Wnt activation followed by Notch inhibition promotes mitotic hair cell regeneration in the postnatal mouse cochlea

Hair cell (HC) loss is the main cause of permanent hearing loss in mammals. Previous studies have reported that in neonatal mice cochleae, Wnt activation promotes supporting cell (SC) proliferation and Notch inhibition promotes the trans-differentiation of SCs into HCs. However, Wnt activation alone...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Ni, Wenli, Zeng, Shan, Li, Wenyan, Chen, Yan, Zhang, Shasha, Tang, Mingliang, Sun, Shan, Chai, Renjie, Li, Huawei
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2016
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5341835/
https://ncbi.nlm.nih.gov/pubmed/27564256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11479
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