Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway

The activation of cochlear progenitor cells is a promising approach for hair cell (HC) regeneration and hearing recovery. The mechanisms underlying the initiation of proliferation of postnatal cochlear progenitor cells and their transdifferentiation to HCs remain to be determined. We show that Notch...

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Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Li, Wenyan, Wu, Jingfang, Yang, Jianming, Sun, Shan, Chai, Renjie, Chen, Zheng-Yi, Li, Huawei
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2015
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291673/
https://ncbi.nlm.nih.gov/pubmed/25535395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1415901112
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